Title : Localization of serotonin 5-HT2 receptors in living human brain by positron emission tomography using N1-([11C]-methyl)-2-Br-LSD.

Pub. Date : 1987

PMID : 2905532






4 Functional Relationships(s)
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1 N1-([11C]-Methyl)-2-Br-LSD ([11C]-MBL) has been developed as a positron emission tomography (PET) imaging agent for serotonin 5-HT2 receptors. Carbon-11 mannose-binding lectin family member 3, pseudogene Homo sapiens
2 Intravenous injection of [11C]-MBL in a baboon led to selective labeling of cortical regions that was markedly blocked by prior administration of ketanserin, a selective 5-HT2 receptor antagonist. Carbon-11 mannose-binding lectin family member 3, pseudogene Homo sapiens
3 Clinical trials with [11C]-MBL have been conducted in seven normal human volunteers, and the regional distribution of radioactivity in the brain was distinctly serotonergic. Carbon-11 mannose-binding lectin family member 3, pseudogene Homo sapiens
4 These studies indicate that [11C]-MBL is a selective radioligand that can be used to monitor serotonin 5-HT2 receptor densities in vivo in most regions of the human brain. Carbon-11 mannose-binding lectin family member 3, pseudogene Homo sapiens