Title : Synergistic antitumor effects of the combined treatment with an HDAC6 inhibitor and a COX-2 inhibitor through activation of PTEN.

Pub. Date : 2017 Nov

PMID : 29048666






3 Functional Relationships(s)
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1 Treatment with celecoxib alone promoted the membrane translocation of phosphatase and tensin homolog (PTEN), indicating PTEN activation, and consequently led to protein kinase B (AKT) dephosphorylation (inactivation). Celecoxib AKT serine/threonine kinase 1 Homo sapiens
2 The combination of celecoxib and an HDAC6 inhibitor synergistically increased PTEN membrane translocation and inactivated AKT. Celecoxib AKT serine/threonine kinase 1 Homo sapiens
3 In summary, the results indicated that the COX-2 inhibitor celecoxib enhanced the HDAC6 inhibitor-induced antitumor effects by activating the PTEN/AKT signaling pathway. Celecoxib AKT serine/threonine kinase 1 Homo sapiens