Title : Analysis of substrate binding in individual active sites of bifunctional human ATIC.

Pub. Date : 2018 Feb

PMID : 29042184






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The majority of nucleotide ligands bind selectively at one of the two active sites with the exception of xanthosine monophosphate, XMP, which, in addition to binding in both AICARFT and IMPCH active sites, shows evidence for cooperative binding with communication between symmetrically-related active sites in the two IMPCH domains. xanthosine monophosphate 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Homo sapiens