Pub. Date : 2017 Oct
PMID : 29042013
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of microsomal prostaglandin E-synthase-1 (mPGES-1) selectively suppresses PGE2 in an in vitro equine inflammation model. | Dinoprostone | prostaglandin E synthase | Mus musculus |
| 2 | One potential target is microsomal prostaglandin E-synthase-1 (mPGES-1), which is the terminal enzyme downstream of COX-2 in the inducible PGE2 synthesis cascade. | Dinoprostone | prostaglandin E synthase | Mus musculus |
| 3 | The objective of this study was to determine if mPGES-1 is a PGE2-selective anti-inflammatory target in equine leukocytes. | Dinoprostone | prostaglandin E synthase | Mus musculus |
| 4 | mPGES-1 inhibition also preserved higher basal levels of PGE2 production when compared to either COX inhibitor, which might be beneficial in a clinical setting. | Dinoprostone | prostaglandin E synthase | Mus musculus |
| 5 | In conclusion, this work identifies mPGES-1 as a key regulator of PGE2 production and a PGE2-selective target in equine leukocytes. | Dinoprostone | prostaglandin E synthase | Mus musculus |
| 6 | In conclusion, this work identifies mPGES-1 as a key regulator of PGE2 production and a PGE2-selective target in equine leukocytes. | Dinoprostone | prostaglandin E synthase | Mus musculus |