Title : MicroRNA‑218 promotes prostaglandin E2 to inhibit osteogenic differentiation in synovial mesenchymal stem cells by targeting 15‑hydroxyprostaglandin dehydrogenase [NAD(+)].

Pub. Date : 2017 Dec

PMID : 29039590






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 MicroRNA-218 promotes prostaglandin E2 to inhibit osteogenic differentiation in synovial mesenchymal stem cells by targeting 15-hydroxyprostaglandin dehydrogenase [NAD(+)]. NAD carbonyl reductase 1 Homo sapiens
2 Western blotting and reverse transcription-quantitative polymerase chain reaction analysis of gene expression demonstrated the upregulation of 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-HPGD), prostaglandin E2 (PGE2) and rate limiting enzymes responsible for the synthesis of PGE2 precursors throughout chondrogenesis. NAD carbonyl reductase 1 Homo sapiens