Pub. Date : 2017 Nov
PMID : 29035366
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. | Glucose | tumor protein p53 | Homo sapiens |
| 2 | Mechanistic studies revealed that after attenuated glucose consumption, Bcl-xL blocks cytoplasmic p53 from triggering intrinsic apoptosis. | Glucose | tumor protein p53 | Homo sapiens |
| 3 | Together, these studies identify a crucial link among oncogene signaling, glucose metabolism, and cytoplasmic p53, which may potentially be exploited for combination therapy in GBM and possibly other malignancies. | Glucose | tumor protein p53 | Homo sapiens |