Title : Investigation of factors affecting the stability of lysozyme spray dried from ethanol-water solutions.

Pub. Date : 2017 Dec 20

PMID : 29031849






4 Functional Relationships(s)
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1 Investigation of factors affecting the stability of lysozyme spray dried from ethanol-water solutions. Water lysozyme Homo sapiens
2 In this study, lysozyme was chosen as a model pharmaceutical protein to study these aspects when spray drying from water-ethanol mixtures. Water lysozyme Homo sapiens
3 Fourier Transform Infrared (FTIR) and Circular Dichroism (CD) results showed that the native structures of lysozyme were largely restored upon reconstitution of the spray dried powder in water after the spray drying process. Water lysozyme Homo sapiens
4 This suggests that the bioactivity of lysozyme could be preserved adequately by optimization of both the formulation composition and process conditions even when spray drying from a water-ethanol mixture. Water lysozyme Homo sapiens