Title : The β-NAD+ salvage pathway and PKC-mediated signaling influence localized PARP-1 activity and CTCF Poly(ADP)ribosylation.

Pub. Date : 2017 Sep 12

PMID : 29029387






2 Functional Relationships(s)
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1 Our findings suggest that CTCF PARylation is underpinned by a cellular metabolic context engendered by regulation of the beta-NAD+ salvage pathway in which NMNAT-1 acts as a rheostat to control localized beta-NAD+ synthesis at CTCF/PARP-1 complexes. NAD nicotinamide nucleotide adenylyltransferase 1 Homo sapiens
2 Our findings suggest that CTCF PARylation is underpinned by a cellular metabolic context engendered by regulation of the beta-NAD+ salvage pathway in which NMNAT-1 acts as a rheostat to control localized beta-NAD+ synthesis at CTCF/PARP-1 complexes. NAD nicotinamide nucleotide adenylyltransferase 1 Homo sapiens