Title : PARP Inhibition by Flavonoids Induced Selective Cell Killing to BRCA2-Deficient Cells.

Pub. Date : 2017 Oct 12

PMID : 29023372






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Quercetin and its glycosides have PARP inhibitory effects and can induce selective cytotoxicity in BRCA2-deficient cells by synthetic lethality. Glycosides LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein Cricetulus griseus
2 We hypothesized that common flavonoids in diet naringenin, hesperetin and their glycosides have a similar structure to quercetin, which might have comparable PARP inhibitory effects, and can induce selective cytotoxicity in BRCA2-deficient cells. Glycosides LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein Cricetulus griseus