Pub. Date : 2017 Nov 6
PMID : 29021150
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we show that the compound CY-09 specifically blocks NLRP3 inflammasome activation. | CY5.5 cyanine dye | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | CY-09 directly binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity, resulting in the suppression of NLRP3 inflammasome assembly and activation. | CY5.5 cyanine dye | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | CY-09 directly binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity, resulting in the suppression of NLRP3 inflammasome assembly and activation. | CY5.5 cyanine dye | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | CY-09 directly binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity, resulting in the suppression of NLRP3 inflammasome assembly and activation. | CY5.5 cyanine dye | NLR family pyrin domain containing 3 | Homo sapiens |