Pub. Date : 2017 Dec
PMID : 29018032
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | After recombinant expression in yeast, human NAT2 exhibited an apparent Lineweaver-Burk constant (K-m) value (20.1 +- 8.8 muM) for hydralazine over 20-fold lower than the apparent K-m value (456 +- 57 muM) for recombinant human NAT1 (P = 0.0016). | Hydralazine | latexin | Homo sapiens |
| 2 | After recombinant expression in yeast, human NAT2 exhibited an apparent Lineweaver-Burk constant (K-m) value (20.1 +- 8.8 muM) for hydralazine over 20-fold lower than the apparent K-m value (456 +- 57 muM) for recombinant human NAT1 (P = 0.0016). | Hydralazine | latexin | Homo sapiens |
| 3 | Hydralazine NAT activities in vitro differed significantly with respect to NAT2 genotype at 1000 (P = 0.0319), 100 (P = 0.002), and 10 muM hydralazine (P = 0.0029). | Hydralazine | latexin | Homo sapiens |
| 4 | The in situ hydralazine N-acetylation rates differed significantly with respect to NAT2 genotype after incubation with 10 (P = 0.002) or 100 microM (P = 0.0015) hydralazine and were higher after incubation with 100 muM (10-fold) than with 10 muM (4.5-fold) hydralazine. | Hydralazine | latexin | Homo sapiens |
| 5 | The in situ hydralazine N-acetylation rates differed significantly with respect to NAT2 genotype after incubation with 10 (P = 0.002) or 100 microM (P = 0.0015) hydralazine and were higher after incubation with 100 muM (10-fold) than with 10 muM (4.5-fold) hydralazine. | Hydralazine | latexin | Homo sapiens |