Pub. Date : 2017
PMID : 28993733
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LncRNA-uc002mbe.2 Interacting with hnRNPA2B1 Mediates AKT Deactivation and p21 Up-Regulation Induced by Trichostatin in Liver Cancer Cells. | trichostatin A | MIR7-3 host gene | Homo sapiens |
| 2 | We previously showed that the induction of lncRNA-uc002mbe.2 is positively associated with the apoptotic effect of trichostatin A (TSA) in hepatocellular carcinoma (HCC) cells. | trichostatin A | MIR7-3 host gene | Homo sapiens |
| 3 | We previously showed that the induction of lncRNA-uc002mbe.2 is positively associated with the apoptotic effect of trichostatin A (TSA) in hepatocellular carcinoma (HCC) cells. | trichostatin A | MIR7-3 host gene | Homo sapiens |
| 4 | The current study further analyzed the role of uc002mbe.2 in TSA-induced liver cancer cell death. | trichostatin A | MIR7-3 host gene | Homo sapiens |
| 5 | The level of uc002mbe.2 was markedly increased by TSA in the cytoplasm of HCC cells. | trichostatin A | MIR7-3 host gene | Homo sapiens |
| 6 | Knockdown of uc002mbe.2 prohibited TSA-induced G2/M cell cycle arrest, p21 induction, and apoptosis of Huh7 cells and reversed the TSA-mediated decrease in p-AKT. | trichostatin A | MIR7-3 host gene | Homo sapiens |
| 7 | Knockdown of uc002mbe.2 prohibited TSA-induced G2/M cell cycle arrest, p21 induction, and apoptosis of Huh7 cells and reversed the TSA-mediated decrease in p-AKT. | trichostatin A | MIR7-3 host gene | Homo sapiens |
| 8 | RNA pull-down and RNA-binding protein immunoprecipitation (RIP) assays revealed that TSA induced an interaction between uc002mbe.2 and heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in Huh7 cells. | trichostatin A | MIR7-3 host gene | Homo sapiens |
| 9 | In an athymic xenograft mouse model, knockdown of uc002mbe.2 significantly prohibited the TSA-mediated reduction in tumor size and weight. | trichostatin A | MIR7-3 host gene | Homo sapiens |
| 10 | In addition, the ability of TSA to reduce hnRNPA2B1 and p-AKT levels and induce p21 in the xenograft tumors was prevented by uc002mbe.2 knockdown. | trichostatin A | MIR7-3 host gene | Homo sapiens |
| 11 | Therefore, the interaction of uc002mbe.2 and hnRNPA2B1 in mediating AKT deactivation and p21 induction is involved in the cytostatic effect of trichostatin in liver cancer cells. | trichostatin A | MIR7-3 host gene | Homo sapiens |