Pub. Date : 2018 Apr 1
PMID : 28992067
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The uremic toxin indoxyl sulfate interferes with iron metabolism by regulating hepcidin in chronic kidney disease. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 2 | Background: Hepcidin secreted by hepatocytes is a key regulator of iron metabolism throughout the body. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 3 | Hepcidin concentrations are increased in chronic kidney disease (CKD), contributing to abnormalities in iron metabolism. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 4 | Conclusions: IS affects iron metabolism in CKD by participating in hepcidin regulation via pathways that depend on AhR and oxidative stress. | Iron | hepcidin antimicrobial peptide | Mus musculus |