Title : IFI16 restoration in hepatocellular carcinoma induces tumour inhibition via activation of p53 signals and inflammasome.

Pub. Date : 2017 Dec

PMID : 28990231






1 Functional Relationships(s)
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1 Mechanistically, IFI16 could activate p53 at Ser15 to up-regulate the p21WAF1/CIP1 level to inhibit tumour growth and migration, which was restored by the p53 inhibitor Pifithrin-alpha (20 mumol/L). pifithrin cyclin dependent kinase inhibitor 1A Homo sapiens