Title : Role of endogenous melatoninergic system in development of hyperalgesia and tolerance induced by chronic morphine administration in rats.

Pub. Date : 2017 Oct

PMID : 28988976






1 Functional Relationships(s)
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1 Comparing with control group (n=6), the group (n=6) of rats with morphine-induced hyperalgesia and tolerance exhibited a significant lower serum melatonin level, reduction in expression of the MT1, but up-regulation of the PKCgamma in the spinal dorsal horn. Morphine protein kinase C, gamma Rattus norvegicus