Pub. Date : 2018 Jan
PMID : 28987423
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Transgenic expression of MIR122 in hepatocytes of mice with ethanol-induced liver disease and advanced fibrosis significantly reduced serum levels of alanine aminotransferase (ALT) and liver steatosis and fibrosis, compared with mice given injections of the control vector. | Ethanol | microRNA 122 | Mus musculus |
| 2 | Ethanol feeding reduced expression of pri-MIR122 by increasing expression of the spliced form of the transcription factor grainyhead like transcription factor 2 (GRHL2) in liver tissues from mice. | Ethanol | microRNA 122 | Mus musculus |
| 3 | Mice given injections of the anti-MIR122 before ethanol feeding had increased steatosis, inflammation, and serum levels of alanine aminotransferase compared with mice given a control vector. | Ethanol | microRNA 122 | Mus musculus |
| 4 | Expression of an anti-MIR122 worsened the severity of liver damage following ethanol feeding in mice. | Ethanol | microRNA 122 | Mus musculus |
| 5 | MIR122 appears to protect the liver from ethanol-induced damage by reducing levels of HIF1alpha. | Ethanol | microRNA 122 | Mus musculus |