Title : Stress inhibits tryptophan hydroxylase expression in a rat model of depression.

Pub. Date : 2017 Sep 8

PMID : 28968985






1 Functional Relationships(s)
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1 All together, stress was able to inhibit expression of TPH1/2 in brain tissue and decrease concentration of 5-HT, the mechanism maybe involve in increasing the methylation of TPH2 genes promoter; Paroxetine has a role in confronting the effect of stress in depressive rat model. Paroxetine tryptophan hydroxylase 2 Rattus norvegicus