Title : Sanguinarine inhibits pancreatic cancer stem cell characteristics by inducing oxidative stress and suppressing sonic hedgehog-Gli-Nanog pathway.

Pub. Date : 2017 Oct 1

PMID : 28968696






1 Functional Relationships(s)
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1 Chromatin immunoprecipitation assay demonstrated that Nanog directly binds to promoters of Cdk2, Cdk6, FGF4, c-Myc and Oct4, and sanguinarine inhibits the binding of Nanog with these genes, suggesting the direct involvement of Nanog in cell cycle, pluripotency and self-renewal. sanguinarine MYC proto-oncogene, bHLH transcription factor Homo sapiens