Title : SNPs near the cysteine proteinase cathepsin O gene (CTSO) determine tamoxifen sensitivity in ERĪ±-positive breast cancer through regulation of BRCA1.

Pub. Date : 2017 Oct

PMID : 28968398






4 Functional Relationships(s)
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1 We previously reported a genome-wide association study that identified common SNPs near the CTSO gene and in ZNF423 associated with development of breast cancer during tamoxifen therapy in the NSABP P-1 and P-2 breast cancer prevention trials. Tamoxifen zinc finger protein 423 Homo sapiens
2 Characterization of the effect of both CTSO SNPs and ZNF423 SNPs on tamoxifen response revealed that cells with different combinations of CTSO and ZNF423 genotypes respond differently to Tamoxifen, PARP inhibitors or the combination of the two drugs due to SNP dependent differential regulation of BRCA1 levels. Tamoxifen zinc finger protein 423 Homo sapiens
3 Characterization of the effect of both CTSO SNPs and ZNF423 SNPs on tamoxifen response revealed that cells with different combinations of CTSO and ZNF423 genotypes respond differently to Tamoxifen, PARP inhibitors or the combination of the two drugs due to SNP dependent differential regulation of BRCA1 levels. Tamoxifen zinc finger protein 423 Homo sapiens
4 Characterization of the effect of both CTSO SNPs and ZNF423 SNPs on tamoxifen response revealed that cells with different combinations of CTSO and ZNF423 genotypes respond differently to Tamoxifen, PARP inhibitors or the combination of the two drugs due to SNP dependent differential regulation of BRCA1 levels. Tamoxifen zinc finger protein 423 Homo sapiens