Pub. Date : 2017 Oct
PMID : 28968398
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We previously reported a genome-wide association study that identified common SNPs near the CTSO gene and in ZNF423 associated with development of breast cancer during tamoxifen therapy in the NSABP P-1 and P-2 breast cancer prevention trials. | Tamoxifen | zinc finger protein 423 | Homo sapiens |
2 | Characterization of the effect of both CTSO SNPs and ZNF423 SNPs on tamoxifen response revealed that cells with different combinations of CTSO and ZNF423 genotypes respond differently to Tamoxifen, PARP inhibitors or the combination of the two drugs due to SNP dependent differential regulation of BRCA1 levels. | Tamoxifen | zinc finger protein 423 | Homo sapiens |
3 | Characterization of the effect of both CTSO SNPs and ZNF423 SNPs on tamoxifen response revealed that cells with different combinations of CTSO and ZNF423 genotypes respond differently to Tamoxifen, PARP inhibitors or the combination of the two drugs due to SNP dependent differential regulation of BRCA1 levels. | Tamoxifen | zinc finger protein 423 | Homo sapiens |
4 | Characterization of the effect of both CTSO SNPs and ZNF423 SNPs on tamoxifen response revealed that cells with different combinations of CTSO and ZNF423 genotypes respond differently to Tamoxifen, PARP inhibitors or the combination of the two drugs due to SNP dependent differential regulation of BRCA1 levels. | Tamoxifen | zinc finger protein 423 | Homo sapiens |