Title : Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation.

Pub. Date : 2017 Dec

PMID : 28964970






1 Functional Relationships(s)
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1 Mechanistically, metformin altered UPR activated by bortezomib, leading to a reduced expression of BiP, up-regulation of CHOP and down-regulation of Bcl-2. Metformin growth differentiation factor 10 Homo sapiens