Title : Pentoxifylline inhibits lipopolysaccharide-induced inflammatory mediators in human second trimester placenta explants.

Pub. Date : 2017 Oct

PMID : 28962697






1 Functional Relationships(s)
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1 RESULTS: PTX preferentially inhibited placental expression and production of LPS-induced pro-inflammatory cytokines including TNF-alpha (25461 vs. 1908 pg/ml, p < 0.001), IL-1beta (2921 vs. 1067 pg/ml, p < 0.001) and IFN-gamma (2190 vs 427 pg/ml, p < 0.001) with relative preservation of anti-inflammatory mediators. Pentoxifylline tumor necrosis factor Homo sapiens