Pub. Date : 2017
PMID : 28955200
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral Nerve Injury. | Clonidine | adrenergic receptor, alpha 2a | Mus musculus |
| 2 | This blocking of cingulate alpha2A adrenoceptors activity abolished the CPP induced by clonidine (0.5 mg/kg intraperitoneally) but not the effects on PWTs at day 7. | Clonidine | adrenergic receptor, alpha 2a | Mus musculus |
| 3 | However, clonidine applied systemically or specifically to the ACC at day 14 increased the PWTs but failed to induce CPP; this negative effect was reversed by the overexpression of cingulate alpha2A adrenoceptors. | Clonidine | adrenergic receptor, alpha 2a | Mus musculus |
| 4 | These results suggest that cingulate alpha2A adrenoceptors are necessary for the analgesic effects of clonidine on spontaneous pain. | Clonidine | adrenergic receptor, alpha 2a | Mus musculus |