Title : Inhibition of rat liver aldehyde dehydrogenases by acrolein.

Pub. Date : 1988 Jan-Feb

PMID : 2894953






3 Functional Relationships(s)
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1 Previous investigations into the enzymatic process responsible for the detoxification of acrolein implicated rat liver aldehyde dehydrogenase (ALDH) in the oxidation of this aldehyde. Acrolein aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus
2 Previous investigations into the enzymatic process responsible for the detoxification of acrolein implicated rat liver aldehyde dehydrogenase (ALDH) in the oxidation of this aldehyde. Acrolein aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus
3 The inhibition is rapid with a 91 and 33% reduction in control mitochondrial and cytosolic ALDH activities, respectively, with a 5-sec preincubation of 30 microM acrolein prior to the addition of the aldehyde substrate. Acrolein aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus