Title : Overexpression of lncRNA IGFBP4-1 reprograms energy metabolism to promote lung cancer progression.

Pub. Date : 2017 Sep 25

PMID : 28946875






1 Functional Relationships(s)
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1 Moreover, we found lnc-IGFBP4-1 could influences ATP production levels and expression of enzymes including HK2, PDK1 and LDHA, in addition, decline in both ATP production and these enzymes in response to 2-DG and 2-DG-combined Rho123, respectively, was observed in lnc-IGFBP4-1-overespressing LC cells, indicative of an enhanced aerobic glycolysis rate. Deoxyglucose hexokinase 2 Homo sapiens