Title : Molecular mechanism for muscarinic M1 receptor-mediated endocytosis of TWIK-related acid-sensitive K+ 1 channels in rat adrenal medullary cells.

Pub. Date : 2017 Nov 15

PMID : 28944482






2 Functional Relationships(s)
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1 This muscarinic signal for the endocytosis was mediated in sequence by phospholipase C (PLC), protein kinase C (PKC), and then the non-receptor tyrosine kinase Src with the consequent tyrosine phosphorylation of TASK1. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
2 We conclude that M1 R stimulation results in internalization of TASK1 channels through the PLC-PKC-Src pathway with the consequent phosphorylation of tyrosine and that this M1 R-mediated internalization is at least in part responsible for muscarinic inhibition of TASK1 channels in rat AM cells. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus