Title : The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading.

Pub. Date : 2018 Apr

PMID : 28942194






2 Functional Relationships(s)
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1 Moreover, OGC silencing promoted hypoxia-induced cardiolipin peroxidation, which reversed the inhibition of cholesterol on the permeabilization of MOM-like liposomes induced by Bax or Bak. Cholesterol solute carrier family 25 member 11 Homo sapiens
2 These findings underscore the selective overexpression of OGC as an adaptive mechanism of HCC to provide adequate mGSH levels in the face of mt-cholesterol loading and suggest that OGC may be a novel therapeutic target for HCC treatment. Cholesterol solute carrier family 25 member 11 Homo sapiens