Pub. Date : 2017 Aug 29
PMID : 28938602
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of cancerous inhibitor of PP2A (CIP2A) contributes to lapatinib resistance through induction of CIP2A-Akt feedback loop in ErbB2-positive breast cancer cells. | Lapatinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | We further demonstrated that lapatinib-induced CIP2A downregulation can be recapitulated by LY294002, suggesting that Akt mediates CIP2A upregulation. | Lapatinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Collectively, our results demonstrate that CIP2A is a molecular target and resistance factor of lapatinib with a critical role in lapatinib-induced cellular responses, including the inhibition of the CIP2A-Akt feedback loop. | Lapatinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Collectively, our results demonstrate that CIP2A is a molecular target and resistance factor of lapatinib with a critical role in lapatinib-induced cellular responses, including the inhibition of the CIP2A-Akt feedback loop. | Lapatinib | AKT serine/threonine kinase 1 | Homo sapiens |