Pub. Date : 2017 Sep 19
PMID : 28934484
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of HuR structure and function by dihydrotanshinone-I. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 2 | The natural product dihydrotanshinone-I (DHTS) prevents the association of HuR and target RNAs in vitro and in cultured cells by interfering with the binding of HuR to RNA. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 3 | The natural product dihydrotanshinone-I (DHTS) prevents the association of HuR and target RNAs in vitro and in cultured cells by interfering with the binding of HuR to RNA. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 4 | The natural product dihydrotanshinone-I (DHTS) prevents the association of HuR and target RNAs in vitro and in cultured cells by interfering with the binding of HuR to RNA. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 5 | The natural product dihydrotanshinone-I (DHTS) prevents the association of HuR and target RNAs in vitro and in cultured cells by interfering with the binding of HuR to RNA. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 6 | Here, we report the structural determinants of the interaction between DHTS and HuR and the impact of DHTS on HuR binding to target mRNAs transcriptome-wide. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 7 | Here, we report the structural determinants of the interaction between DHTS and HuR and the impact of DHTS on HuR binding to target mRNAs transcriptome-wide. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 8 | NMR titration and Molecular Dynamics simulation identified the residues within RRM1 and RRM2 responsible for the interaction between DHTS and HuR. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 9 | RNA Electromobility Shifts and Alpha Screen Assays showed that DHTS interacts with HuR through the same binding regions as target RNAs, stabilizing HuR in a locked conformation that hampers RNA binding competitively. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 10 | RNA Electromobility Shifts and Alpha Screen Assays showed that DHTS interacts with HuR through the same binding regions as target RNAs, stabilizing HuR in a locked conformation that hampers RNA binding competitively. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 11 | In vivo, DHTS potently inhibited xenograft tumor growth in a HuR-dependent model without systemic toxicity. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |