Title : The effects of the antimuscarinic drugs pirenzepine and atropine on plasma portal levels of somatostatin and gastrin in the dog.

Pub. Date : 1987 Oct

PMID : 2892879






3 Functional Relationships(s)
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1 Iv bolus administration of pirenzepine (1 mg/kg) or atropine (0.1 mg/kg), decreased gastrin concentrations, but did not affect basal somatostatin levels. Pirenzepine gastrin Canis lupus familiaris
2 Pirenzepine (1 mg/kg iv bolus), administered at the 60th min of bethanechol infusion, decreased the gastrin concentrations, and markedly enhanced somatostatin levels. Pirenzepine gastrin Canis lupus familiaris
3 These results indicate that muscarinic receptors with similar affinity for pirenzepine and atropine mediate excitatory cholinergic influences on gastrin release. Pirenzepine gastrin Canis lupus familiaris