Pub. Date : 2017 Jul
PMID : 28918747
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Omega-3 Polyunsaturated Fatty Acids Eicosapentaenoic Acid and Docosahexaenoic Acid Enhance Dexamethasone Sensitivity in Multiple Myeloma Cells by the p53/miR-34a/Bcl-2 Axis. | Dexamethasone | tumor protein p53 | Homo sapiens |
| 2 | In addition, we observed that PUFAs induced p53 protein expression in MM cells under dexamethasone administration. | Dexamethasone | tumor protein p53 | Homo sapiens |
| 3 | Furthermore, suppressing p53 by its inhibitor, Pifithrin-alpha, regulated the miR-34a expression and modulated the sensitivity to dexamethasone in U266 cells. | Dexamethasone | tumor protein p53 | Homo sapiens |
| 4 | In summary, these results suggest that PUFAs enhance dexamethasone sensitivity to MM cells through the p53/miR-34a axis with a likely contribution of Bcl-2 suppression. | Dexamethasone | tumor protein p53 | Homo sapiens |