Title : Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction.

Pub. Date : 2017 Oct

PMID : 28913661






1 Functional Relationships(s)
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1 In this study, we generated an energy-based pharmacophore model by using the crystal structure of CypD-cyclosporine A (CsA) complex and performed virtual screening of ChemDiv database, which yielded forty-five potential hit compounds with novel scaffolds. Cyclosporine peptidylprolyl isomerase D Homo sapiens