Title : Aspirin inhibits LPS-induced macrophage activation via the NF-κB pathway.

Pub. Date : 2017 Sep 14

PMID : 28912509






1 Functional Relationships(s)
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1 We found that ASA could downregulate the expressions of iNOS and TNF-alpha both in mouse peritoneum macrophages and RAW264.7 cells induced by LPS via the IkappaK/IkappaB/NF-kappaB pathway and a COX2/PGE2/EP2/NF-kappaB feedback loop, without affecting the expressions of FIZZ/YM-1/ARG1 induced by IL-4. Dinoprostone nitric oxide synthase 2, inducible Mus musculus