Title : Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response.

Pub. Date : 2017 Sep

PMID : 28902916






1 Functional Relationships(s)
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1 We focused on the conserved CD4 binding site (CD4bs) since this is a known neutralizing determinant that is devoid of glycosylation to allow CD4 receptor engagement, but is ringed by surrounding N-glycans. cd4bs T-cell surface glycoprotein CD4 Oryctolagus cuniculus