Title : The antitumor effects of arsenic trioxide in mantle cell lymphoma via targeting Wnt/β‑catenin pathway and DNA methyltransferase-1.

Pub. Date : 2017 Nov

PMID : 28901456






1 Functional Relationships(s)
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1 In this study, ATO was shown to promote apoptosis and to inhibit cell viability in MCL cell lines, whereas, the expression of DNA methyltransferase-1 (DNMT-1), beta-catenin and the downstream molecules of Wnt/beta-catenin pathway such as c-myc, cyclin D1 and MMP7 were all decreased in a dose-dependent manner with ATO. ato MYC proto-oncogene, bHLH transcription factor Homo sapiens