Title : Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols.

Pub. Date : 2017 Sep 12

PMID : 28900196






1 Functional Relationships(s)
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1 Inhibition of RORalpha and RORgamma transactivation activities in a Tet-on CHO cell reporter system, RORalpha co-activator assays and inhibition of (RORE)-LUC reporter activity in skin cells, in conjunction with molecular modeling, identified RORalpha and RORgamma as excellent receptor candidates for the hydroxylumisterols. tetramethylenedisulfotetramine nuclear receptor ROR-alpha Cricetulus griseus