Title : Serotonin augmentation therapy by escitalopram has minimal effects on amyloid-β levels in early-stage Alzheimer's-like disease in mice.

Pub. Date : 2017 Sep 12

PMID : 28899417






1 Functional Relationships(s)
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1 CONCLUSIONS: Because this study shows that modulation of the 5-HTergic system has either no effect or increases levels of insoluble/soluble Abeta42 and Abeta40 in the cerebral cortex of APP/PS1 mice, our observations do not support 5-HT augmentation therapy as a preventive strategy for reducing Abeta pathology. Serotonin presenilin 1 Mus musculus