Title : Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.

Pub. Date : 2017 Dec

PMID : 28895472






1 Functional Relationships(s)
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1 INTRODUCTION: AKR1C3 is a drug target in hormonal and hormonal independent malignancies and acts as a major peripheral 17beta-hydroxysteroid dehydrogenase to yield the potent androgens testosterone and dihydrotestosterone, and as a prostaglandin (PG) F synthase to produce proliferative ligands for the PG FP receptor. Testosterone hydroxysteroid 17-beta dehydrogenase 7 Homo sapiens