Title : Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis.

Pub. Date : 2017 Oct 20

PMID : 28878015






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Recombinant Trx1 preferentially binds to monomeric MLKL and blocks MLKL disulfide bond formation and polymerization in vitro Inhibition of MLKL polymer formation requires the reducing activity of Trx1. Disulfides thioredoxin Homo sapiens
2 Recombinant Trx1 preferentially binds to monomeric MLKL and blocks MLKL disulfide bond formation and polymerization in vitro Inhibition of MLKL polymer formation requires the reducing activity of Trx1. Disulfides thioredoxin Homo sapiens