Title : Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins.

Pub. Date : 2017 Sep 5

PMID : 28874603






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 An Arg-to-His, but not Arg-to-Lys, mutation in the transcription factor p53 (p53-R273H) decreased its transcriptional activity and attenuated the DNA damage response in fibroblasts and breast cancer cells with high pHi. Arginine tumor protein p53 Homo sapiens
2 An Arg-to-His, but not Arg-to-Lys, mutation in the transcription factor p53 (p53-R273H) decreased its transcriptional activity and attenuated the DNA damage response in fibroblasts and breast cancer cells with high pHi. Arginine tumor protein p53 Homo sapiens