Title : The effects of UDP-sugars, UDP and Mg2+on uridine diphosphate glucuronosyltransferase activity in human liver microsomes.

Pub. Date : 2018 Sep

PMID : 28868965






4 Functional Relationships(s)
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1 We examined inhibition of UGT activity in alamethicin-disrupted human liver microsomes (HLM) by uridine diphosphate (UDP), a UGT reaction product, and its reversal by Mg2+ ions. Uridine Diphosphate UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens
2 We examined inhibition of UGT activity in alamethicin-disrupted human liver microsomes (HLM) by uridine diphosphate (UDP), a UGT reaction product, and its reversal by Mg2+ ions. Uridine Diphosphate UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens
3 We examined inhibition of UGT activity in alamethicin-disrupted human liver microsomes (HLM) by uridine diphosphate (UDP), a UGT reaction product, and its reversal by Mg2+ ions. Uridine Diphosphate UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens
4 We also demonstrate that UDP inhibits HLM UGT activity and that this is reversed by including Mg2+ in the assay. Uridine Diphosphate UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens