Title : Second Generation Grp94-Selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer.

Pub. Date : 2017 Nov 7

PMID : 28857290






2 Functional Relationships(s)
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1 Modification of the first generation cis-amide bioisostere imidazole to alter the angle between the resorcinol ring and the benzyl side chain via cis-amide replacements produced compounds with improved Grp94 affinity and selectivity. cis-amide heat shock protein 90 beta family member 1 Homo sapiens
2 Modification of the first generation cis-amide bioisostere imidazole to alter the angle between the resorcinol ring and the benzyl side chain via cis-amide replacements produced compounds with improved Grp94 affinity and selectivity. cis-amide heat shock protein 90 beta family member 1 Homo sapiens