Pub. Date : 2017
PMID : 28854439
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | mPGES-1-Derived PGE2 Contributes to Indoxyl Sulfate-Induced Mesangial Cell Proliferation. | Dinoprostone | prostaglandin E synthase | Mus musculus |
| 2 | Thus, the present study was undertaken to examine the role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived Prostaglandin E2 (PGE2) in IS-induced MC proliferation. | Dinoprostone | prostaglandin E synthase | Mus musculus |
| 3 | Thus, the present study was undertaken to examine the role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived Prostaglandin E2 (PGE2) in IS-induced MC proliferation. | Dinoprostone | prostaglandin E synthase | Mus musculus |
| 4 | Interestingly, silencing mPGES-1 reduced cell number in S and G2 phases and blocked the upregulation of cyclin A2 and cyclin D1 in parallel with blunted PGE2 release after IS treatment, indicating that mPGES-1-derived PGE2 could contribute to MC proliferation. | Dinoprostone | prostaglandin E synthase | Mus musculus |
| 5 | Interestingly, silencing mPGES-1 reduced cell number in S and G2 phases and blocked the upregulation of cyclin A2 and cyclin D1 in parallel with blunted PGE2 release after IS treatment, indicating that mPGES-1-derived PGE2 could contribute to MC proliferation. | Dinoprostone | prostaglandin E synthase | Mus musculus |
| 6 | Interestingly, silencing mPGES-1 reduced cell number in S and G2 phases and blocked the upregulation of cyclin A2 and cyclin D1 in parallel with blunted PGE2 release after IS treatment, indicating that mPGES-1-derived PGE2 could contribute to MC proliferation. | Dinoprostone | prostaglandin E synthase | Mus musculus |
| 7 | CONCLUSION: mPGES-1-derived PGE2 contributed to IS-induced mesangial cell proliferation. | Dinoprostone | prostaglandin E synthase | Mus musculus |