Title : Individualized drug screening based on next generation sequencing and patient derived xenograft model for pancreatic cancer with bone metastasis.

Pub. Date : 2017 Oct

PMID : 28849200






3 Functional Relationships(s)
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1 Based on the sequencing results and associated literatures, AZD6244, a highly selective inhibitor against mitogen-activated protein kinase kinase 1 (MEK1), was chosen as a potential therapy. AZD 6244 mitogen-activated protein kinase kinase 1 Homo sapiens
2 Based on the sequencing results and associated literatures, AZD6244, a highly selective inhibitor against mitogen-activated protein kinase kinase 1 (MEK1), was chosen as a potential therapy. AZD 6244 mitogen-activated protein kinase kinase 1 Homo sapiens
3 AZD6244, a highly selective MEK1 inhibitor, was evaluated as effective for the pancreatic cancer PDX model, and thus may provide potential efficacy in the clinical treatment of the patient with pancreatic cancer investigated in the present study. AZD 6244 mitogen-activated protein kinase kinase 1 Homo sapiens