Pub. Date : 2017 Oct
PMID : 28849090
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | H2O2 markedly upregulated the expression levels of KLF4 and KLF5, and downregulated the expression levels of miR-506 and miR-124 in the HCMs. | Hydrogen Peroxide | microRNA 506 | Homo sapiens |
| 2 | The overexpression of miR-506 and miR-124 inhibited the H2O2-induced upregulation of KLF4 and KLF5 in the HCMs. | Hydrogen Peroxide | microRNA 506 | Homo sapiens |
| 3 | The overexpression of miR-506 and miR-214 reversed the H2O2-induced apoptosis and increase of ROS in the HCMs. | Hydrogen Peroxide | microRNA 506 | Homo sapiens |
| 4 | In conclusion, the overexpression of miR-506 and miR-214 were confirmed to have a protective effect against H2O2-induced HCM injury by suppressing the expression of KLF4 and KLF5. | Hydrogen Peroxide | microRNA 506 | Homo sapiens |