Title : Regulation of HGF-induced hepatocyte proliferation by the small GTPase Arf6 through the PIP2-producing enzyme PIP5K1A.

Pub. Date : 2017 Aug 25

PMID : 28842595






1 Functional Relationships(s)
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1 We find that knockdown of Arf6 and PIP5K1A in HepG2 cells inhibits HGF-stimulated proliferation, Akt activation, and generation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) and its precursor PIP2. PIP3 phosphatidylinositol-4-phosphate 5-kinase type 1 alpha Homo sapiens