Pub. Date : 2017 Aug 24
PMID : 28835610
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation. | Glutamine | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | In this study, we investigate the role of autophagy and glutamine on the regulation of mTORC1, a critical kinase that regulates cell growth and proliferation. | Glutamine | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | We report that supplementation of glutamine alone is sufficient to restore mTORC1 activity during prolonged amino acid starvation. | Glutamine | CREB regulated transcription coactivator 1 | Mus musculus |
| 4 | Inhibition of autophagy abolishes the restorative effect of glutamine, suggesting that reactivation of mTORC1 is autophagy-dependent. | Glutamine | CREB regulated transcription coactivator 1 | Mus musculus |
| 5 | Inhibition of glutaminolysis or transamination impairs glutamine-mediated mTORC1 reactivation, suggesting glutamine reactivates mTORC1 specifically through its conversion to glutamate and restoration of non-essential amino acid pool. | Glutamine | CREB regulated transcription coactivator 1 | Mus musculus |
| 6 | Inhibition of glutaminolysis or transamination impairs glutamine-mediated mTORC1 reactivation, suggesting glutamine reactivates mTORC1 specifically through its conversion to glutamate and restoration of non-essential amino acid pool. | Glutamine | CREB regulated transcription coactivator 1 | Mus musculus |
| 7 | Inhibition of glutaminolysis or transamination impairs glutamine-mediated mTORC1 reactivation, suggesting glutamine reactivates mTORC1 specifically through its conversion to glutamate and restoration of non-essential amino acid pool. | Glutamine | CREB regulated transcription coactivator 1 | Mus musculus |
| 8 | Inhibition of glutaminolysis or transamination impairs glutamine-mediated mTORC1 reactivation, suggesting glutamine reactivates mTORC1 specifically through its conversion to glutamate and restoration of non-essential amino acid pool. | Glutamine | CREB regulated transcription coactivator 1 | Mus musculus |
| 9 | Despite a persistent drop in essential amino acid pool during amino acid starvation, crosstalk between glutamine and autophagy is sufficient to restore insulin sensitivity of mTORC1. | Glutamine | CREB regulated transcription coactivator 1 | Mus musculus |
| 10 | Thus, glutamine metabolism and autophagy constitute a specific metabolic program which restores mTORC1 activity during amino acid starvation.mTORC1 is a critical kinase that regulates cell growth and proliferation. | Glutamine | CREB regulated transcription coactivator 1 | Mus musculus |
| 11 | Thus, glutamine metabolism and autophagy constitute a specific metabolic program which restores mTORC1 activity during amino acid starvation.mTORC1 is a critical kinase that regulates cell growth and proliferation. | Glutamine | CREB regulated transcription coactivator 1 | Mus musculus |
| 12 | Here the authors show that glutamine metabolism is sufficient to restore mTORC1 activity during prolonged amino acid starvation in an autophagy-dependent manner. | Glutamine | CREB regulated transcription coactivator 1 | Mus musculus |