Title : Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover.

Pub. Date : 2017 Sep 19

PMID : 28816437






1 Functional Relationships(s)
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1 On the basis of complex crystal structures, we investigate the inactivation mechanism of OAT, a hepatocellular carcinoma target, by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP), a known inactivator of GABA-AT. CHEMBL163117 4-aminobutyrate aminotransferase Homo sapiens