Pub. Date : 2017 Oct 25
PMID : 28803208
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | N-glucuronidation catalyzed by UGT1A4 and UGT2B10 in human liver microsomes: Assay optimization and substrate identification. | Nitrogen | UDP glucuronosyltransferase family 2 member B10 | Homo sapiens |
| 2 | However, the metabolic patterns of UGT1A4- and UGT2B10-mediated N-glucuronidation are not fully clear. | Nitrogen | UDP glucuronosyltransferase family 2 member B10 | Homo sapiens |
| 3 | In this study, we first optimized in vitro reaction conditions for N-glucuronidation by using specific substrates (i.e., trifluoperazine for UGT1A4, cotinine and amitriptyline for UGT2B10). | Nitrogen | UDP glucuronosyltransferase family 2 member B10 | Homo sapiens |
| 4 | In addition, UGT1A4 and UGT2B10 were primarily responsible for N-glucuronidation of many tertiary amines, including asenapine, loxapine, clozapine, chlorpromazine, dothiepin, doxepin, mirtazapine, mianserin, chlorcyclizine, cyclizine, promethazine, cyclobenzaprine, imatinib, retrorsine, strychnine and brucine. | Nitrogen | UDP glucuronosyltransferase family 2 member B10 | Homo sapiens |
| 5 | Also, UGT1A4- and UGT2B10-mediated N-glucuronidation might play significant roles in metabolism and detoxification of tertiary amines in humans. | Nitrogen | UDP glucuronosyltransferase family 2 member B10 | Homo sapiens |