Title : N-glucuronidation catalyzed by UGT1A4 and UGT2B10 in human liver microsomes: Assay optimization and substrate identification.

Pub. Date : 2017 Oct 25

PMID : 28803208






1 Functional Relationships(s)
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1 In addition, UGT1A4 and UGT2B10 were primarily responsible for N-glucuronidation of many tertiary amines, including asenapine, loxapine, clozapine, chlorpromazine, dothiepin, doxepin, mirtazapine, mianserin, chlorcyclizine, cyclizine, promethazine, cyclobenzaprine, imatinib, retrorsine, strychnine and brucine. Chlorpromazine UDP glucuronosyltransferase family 1 member A4 Homo sapiens