Pub. Date : 2017 Aug 11
PMID : 28798402
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Nutlin-3 enhances the bortezomib sensitivity of p53-defective cancer cells by inducing paraptosis. | Bortezomib | tumor protein p53 | Homo sapiens |
2 | In this study, we show that treatment of various p53-defective bortezomib-resistant solid tumor cells with bortezomib plus nutlin-3 induces paraptosis, which is a cell death mode accompanied by dilation of the endoplasmic reticulum (ER) and mitochondria. | Bortezomib | tumor protein p53 | Homo sapiens |
3 | In this study, we show that treatment of various p53-defective bortezomib-resistant solid tumor cells with bortezomib plus nutlin-3 induces paraptosis, which is a cell death mode accompanied by dilation of the endoplasmic reticulum (ER) and mitochondria. | Bortezomib | tumor protein p53 | Homo sapiens |